STABILITY EVALUATION OF DEFORMATION (DENUDATION) OF YUANJUE ROCK CAVE ROOF BASED ON MULTISOURCE MONITORING



Calcium Increase and Substance P Release Induced by the Neurotoxin Brevetoxin-1 in Sensory Neurons: Involvement of PAR2 Activation through Both Cathepsin S and Canonical Signaling

Red tides involving Karenia brevis expose humans to brevetoxins (PbTxs).Oral exposition triggers neurotoxic shellfish poisoning, whereas inhalation induces a respiratory syndrome and sensory disturbances.No curative treatment is available and the pathophysiology is not fully elucidated.Protease-activated receptor 2 (PAR2), cathepsin S (Cat-S) and s

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Observing one-divalent-metal-ion-dependent and histidine-promoted His-Me family I-PpoI nuclease catalysis in crystallo

Metal-ion-dependent nucleases play crucial roles in cellular defense and biotechnological applications.Time-resolved crystallography has resolved catalytic details of metal-ion-dependent DNA hydrolysis and synthesis, uncovering the essential roles of multiple metal ions during catalysis.The histidine-metal (His-Me) superfamily nucleases are click h

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Modern simulation utilities for genetic analysis

Abstract Background Statistical geneticists employ simulation a&d ej-123 to estimate the power of proposed studies, test new analysis tools, and evaluate properties of causal models.Although there are existing trait simulators, there is ample room for modernization.For example, most phenotype simulators are limited to Gaussian traits or traits tran

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